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Article

Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder.

Journal of psychopharmacology (Oxford, England) - 1 Oct 2016

Furmark Tomas, Marteinsdottir Ina, Frick Andreas, Heurling Kerstin, Tillfors Maria, Appel Lieuwe, Antoni Gunnar, Hartvig Per, Fischer Håkan, Långström Bengt, Eriksson Elias, Fredrikson Mats

Abstract excerpt

It is disputed whether anxiety disorders, like social anxiety disorder, are characterized by serotonin over- or underactivity. Here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (TPH2) G-703T polymorphism relates to differences in...

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Source

Identifiers

PMID: 27189957
DOI: 10.1177/0269881116648317

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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