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Article

A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2008

Furmark Tomas, Appel Lieuwe, Henningsson Susanne, Ahs Fredrik, Faria Vanda, Linnman Clas, Pissiota Anna, Frans Orjan, Bani Massimo, Bettica Paolo, Pich Emilio Merlo, Jacobsson Eva, Wahlstedt Kurt, Oreland Lars, Långström Bengt, Eriksson Elias, Fredrikson Mats

Abstract excerpt

Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond to placebo are widely unknown. Here, we used functional neuroimaging to examine neural correlates of anxiety reduction resulting from sustained placebo treatment under randomized double-blind conditions, in patients with social anxiety disorder. Brain activity was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19052197
DOI: 10.1523/JNEUROSCI.2534-08.2008
PMCID: PMC6671592

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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