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Article

Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation.

PLoS pathogens - 1 May 2016

Delviks-Frankenberry Krista A, Nikolaitchik Olga A, Burdick Ryan C, Gorelick Robert J, Keele Brandon F, Hu Wei-Shau, Pathak Vinay K

Abstract excerpt

Although the predominant effect of host restriction APOBEC3 proteins on HIV-1 infection is to block viral replication, they might inadvertently increase retroviral genetic variation by inducing G-to-A hypermutation. Numerous studies have disagreed on the contribution of hypermutation to viral genetic diversity and evolution. Confounding factors contributing to the debate include the extent of lethal (stop codon)...

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Source

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Identifiers

PMID: 27186986
DOI: 10.1371/journal.ppat.1005646
PMCID: PMC4871359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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