Article
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Jayaram Hariharan, Hoelper Dominik, Jain Siddhant U, Cantone Nico, Lundgren Stefan M, Poy Florence, Allis C David, Cummings Richard, Bellon Steven, Lewis Peter W
Abstract excerpt
Lysine to methionine (K-to-M) mutations in genes encoding histone H3 are thought to drive a subset of pediatric brain and bone cancers. These high-frequency K-to-M mutations occur at sites of methylation on histone H3, and tumors containing the mutant histones exhibit a global loss of specific histone methylation marks. Previous studies showed that K-to-M mutant histones, also known as oncohistones, are potent...
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