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Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate

9 May 2022

Abstract excerpt

Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have associated DMPA use with genital epithelial barrier disruption and mucosal influx of human immunodeficiency virus (HIV) target cells. We explored the underlying molecular mechanisms of these findings. Ectocervical biopsies and cervicovaginal lavage (CVL)...

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PMID: 35533147
DOI: 10.1371/journal.ppat.1010494

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