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Article

Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting.

Prostate cancer and prostatic diseases - 1 Sept 2016

Antonarakis E S, Armstrong A J, Dehm S M, Luo J

Abstract excerpt

While there are myriad mechanisms of primary and acquired resistance to conventional and next-generation hormonal therapies in prostate cancer, the potential role of androgen receptor splice variants (AR-Vs) has recently gained momentum. AR-Vs are abnormally truncated isoforms of the androgen receptor (AR) protein that lack the COOH-terminal domain but retain the NH2-terminal domain and DNA-binding domain and are...

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Source

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Identifiers

PMID: 27184811
DOI: 10.1038/pcan.2016.17
PMCID: PMC5493501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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