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Article

[The impact of the androgen receptor splice variant AR-V7 on the prognosis and treatment of advanced prostate cancer].

Aktuelle Urologie - 1 Dec 2020

Thelen P, Taubert H, Duensing S, Kristiansen G, Merseburger A S, Cronauer M V

Abstract excerpt

A recently discovered mechanism enabling prostate cancer cells to escape the effects of endocrine therapies consists in the synthesis of C-terminally truncated, constitutively active androgen receptor (AR) splice variants (AR-V). Devoid of a functional C-terminal hormone/ligand binding domain, various AR-Vs are insensitive to therapies targeting the androgen/AR signalling axis. Preliminary studies suggest that...

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PMID: 29370587
DOI: 10.1055/s-0043-115426

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