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Article

Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes.

Cancer genetics - 1 Jun 2016

Salari Azam, Thomay Kathrin, Himmler Kirsten, Vajen Beate, Schienke Andrea, Hagedorn Maike, Ebersold Juliane, Kreipe Hans-Heinrich, Krüger Andreas, Schambach Axel, Schlegelberger Brigitte, Göhring Gudrun

Abstract excerpt

Myelodysplastic syndromes (MDS) are difficult to culture long-term showing the need of a model to study the fate of cells with MDS-abnormalities associated with chromosomal instability (CIN). This approach to establish a xenograft model transplanting human hematopoietic stem cells (HSC) with different independent lentivirally-mediated MDS-related modifications into immunodeficient mice is a long-lasting and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27184732
DOI: 10.1016/j.cancergen.2016.04.004

Genes

RPS14

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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