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Article

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.

Scientific reports - 15 Jul 2020

Dobson Philip F, Dennis Ella P, Hipps Daniel, Reeve Amy, Laude Alex, Bradshaw Carla, Stamp Craig, Smith Anna, Deehan David J, Turnbull Doug M, Greaves Laura C

Abstract excerpt

The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to the ageing process. To explore the potential effects of mtDNA mutations on bone biology, we compared bone microarchitecture and turnover in an ageing series of wild...

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Share to Bone Resorption
Share to Calcification, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

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Identifiers

PMID: 32669663
DOI: 10.1038/s41598-020-68566-2
PMCID: PMC7363892

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