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Selective Modulation of Superantigen‐Induced Responses by Streptococcal Cysteine Protease

1 Feb 2003

Abstract excerpt

Streptococcal pyrogenic exotoxin (Spe) B, a streptococcal cysteine protease, is believed to be important in group A streptococcal (GAS) pathogenesis. The present study examined the effect of SpeB on the activity of superantigenic exotoxins secreted by M1T1 GAS isolates. The proliferative response of human lymphocytes to culture supernatant (SUP) from an SpeB(+) isolate increased significantly (P<.05) when the...

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PMID: 12552423
DOI: 10.1086/368022

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