Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

doi:10.2217/pgs.16.16

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Article

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Pharmacogenomics - 1 May 2016

Smith Samantha Louise, Plant Darren, Lee Xiu Hue, Massey Jonathan, Hyrich Kimme, Morgan Ann W, Wilson Anthony G, Isaacs John, Barton Anne

Abstract excerpt

AIM: A genetic variant has recently reached genome-wide significance for association with TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication study in a UK Caucasian population to test for association with TNF-inhibitor response. MATERIALS & METHODS: The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response...

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PMID: 27180831
DOI: 10.2217/pgs.16.16
PMCID: PMC4996314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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