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Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients

14 May 2016

Abstract excerpt

BACKGROUND: It was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an earlier study that exposure of immortalized human embryonic kidney cells (HEK 293) to cancer patient sera, induce their transformation into undifferentiated cancers due to a horizontal transfer...

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PMID: 27179759
DOI: 10.1186/s13046-016-0360-9

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