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Article

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment.

PloS one - 1 Jan 2017

Zhou Shufeng, Abdouh Mohamed, Arena Vincenzo, Arena Manuel, Arena Goffredo Orazio

Abstract excerpt

The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes. In an analogous manner, mimicking an early embryonic environment during embryonic stem cell culture has been shown to suppress oncogenic phenotypes of cancer cells. Exosomes derived from human embryonic stem cells harbor substances that...

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PMID: 28068409
DOI: 10.1371/journal.pone.0169899
PMCID: PMC5222525

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SOX2

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