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Article

Whole-exome sequencing reveals novel genomic signatures and potential therapeutic targets during the progression of rectal neuroendocrine neoplasm.

Cell death & disease - 15 Nov 2024

Xu Shi, Zhai Zhi Yong, Zhou Ping, Xue Xiu Fen, Huang Zhao Yu, Li Xia Xi, Yang Gen Hua, Bao Chong Ju, You Li Juan, Cui Xiao Bing, Xia Gui Li, Ou Yang Mei Ping, Li Long Fei, Lu Lan, Gong Wei, Pei Xiao Juan, Hu Wei

Abstract excerpt

Rectal neuroendocrine neoplasms (rNENs) are among the most frequent gastrointestinal neuroendocrine neoplasms and pose a serious challenge for clinical management. The size of the primary neoplasm is considered to be the most important predictor of disease progression, but the genetic alterations that occur during the progression of rNENs remain unknown. Here, we performed a comprehensive whole-exome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39548061
DOI: 10.1038/s41419-024-07232-1
PMCID: PMC11568169

Genes

BAG2
MAN2A1
MUC16
MUC4
RHPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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