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Dual-Reporter Mycobacteriophages (Φ 2 DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

26 Oct 2016

Abstract excerpt

ABSTRACT Persisters are the minor subpopulation of bacterial cells that lack alleles conferring resistance to a specific bactericidal antibiotic but can survive otherwise lethal concentrations of that antibiotic. In infections with Mycobacterium tuberculosis , such persisters underlie the need for long-term antibiotic therapy and contribute to treatment failure in tuberculosis cases. Here, we demonstrate the...

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PMID: 27795387
DOI: 10.1128/mbio.01023-16

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