Article
A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients.
Gastroenterology - 1 Nov 2014
Debing Yannick, Gisa Anett, Dallmeier Kai, Pischke Sven, Bremer Birgit, Manns Michael, Wedemeyer Heiner, Suneetha Pothakamuri Venkata, Neyts Johan
Abstract excerpt
We analyzed blood samples collected from 15 patients with chronic hepatitis E who were recipients of solid-organ transplants. All patients cleared the hepatitis E virus (HEV) except for 2 (nonresponders); 1 patient died. A G1634R mutation in viral polymerase was detected in the HEV RNA of the nonresponders; this mutation did not provide the virus with resistance to ribavirin in vitro. However, the mutant form of...
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