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Modeling and fitting protein-protein complexes to predict change of binding energy.

Scientific reports - 13 May 2016

Dourado Daniel F A R, Flores Samuel Coulbourn

Abstract excerpt

It is possible to accurately and economically predict change in protein-protein interaction energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available. This is of growing usefulness for design of high-affinity or otherwise modified binding proteins for therapeutic, diagnostic, industrial, and basic science applications. Recently the field has begun to pursue ΔΔG prediction for...

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PMID: 27173910
DOI: 10.1038/srep25406
PMCID: PMC4865953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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