Article
CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients.
Cytokine - 1 Aug 2011
de Oliveira Karen Brajão, Guembarovski Roberta Losi, Oda Julie Massayo Maeda, Mantovani Mário Sérgio, Carrera Clisia Mara, Reiche Edna Maria Vissoci, Voltarelli Julio Cesar, da Silva do Amaral Herrera Ana Cristina, Watanabe Maria Angelica Ehara
Abstract excerpt
The role of chemokines has been extensively analyzed both in cancer risk and tumor progression. Among different cytokines, CXCR4 and its ligand CXCL12 have been recently subjected to a closer examination. The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/SDF1-3'A) in the CXCL12 gene and the relative expression of mRNA CXCL12 in peripheral blood were assessed in breast cancer...
Topics
- Alleles
- Breast Neoplasms
- Chemokine CXCL12
- Female
- Genotype
- Humans
- Polymorphism, Single Nucleotide
- RNA, Messenger