Article
CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer.
Clinical and experimental medicine - 1 Aug 2013
de Oliveira Karen Brajão, Guembarovski Roberta Losi, Guembarovski Alda Maria Fiorina Losi, da Silva do Amaral Herrera Ana Cristina, Sobrinho Walter Jorge, Ariza Carolina Batista, Watanabe Maria Angelica Ehara
Abstract excerpt
Signals from the microenvironment have a profound influence on the maintenance or progression of breast cancer. In the present study, the frequency of CXCL12 rs1801157 polymorphism in peripheral blood and the expression of CXCL12, CXCR4 and IFNγ mRNA in normal and mammary gland tumor tissues were assessed in breast cancer patients. Genotyping was performed by polymerase chain reaction followed by restriction...
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