Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HSF1-deficiency affects gait coordination and cerebellar calbindin levels.

Behavioural brain research - 1 Sept 2016

Ingenwerth Marc, Estrada Veronica, Stahr Anna, Müller Hans Werner, von Gall Charlotte

Abstract excerpt

Heat shock proteins (HSPs) play an important role in cell homeostasis and protect against cell damage. They were previously identified as key players in different ataxia models. HSF1 is the main transcription factor for HSP activation. HSF1-deficient mice (HSF1-/-) are known to have deficiencies in motor control test. However, little is known about effects of HSF1-deficiency on locomotor, especially gait,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia
Share to Automation, Laboratory
Share to Biomechanical Phenomena

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calbindins

Share to Data Mining

Share to Heat Shock Transcription Factors

Share to Pattern Recognition, Automated

Source

Identifiers

PMID: 27173427
DOI: 10.1016/j.bbr.2016.05.015

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HSF1-deficiency affects gait coordination and cerebellar calbindin levels.PMID 27173427Read ↗

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice.Semantic proximity Read ↗

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse modelsSemantic proximity Read ↗

Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic DensitySemantic proximity Read ↗

An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.Semantic proximity Read ↗

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's diseaseSemantic proximity Read ↗

Heat Shock Transcription Factor 1 Is Required for Maintenance of Ciliary Beating in MiceSemantic proximity Read ↗

Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin.Semantic proximity Read ↗

Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.Semantic proximity Read ↗

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's diseaseSemantic proximity Read ↗

HSF1 functions as a transcription regulator for Dp71 expression.Semantic proximity Read ↗

Disruption of Heat Shock Factor 1 Reveals an Essential Role in the Ubiquitin Proteolytic PathwaySemantic proximity Read ↗

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.