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Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

7 Jun 2022

Abstract excerpt

Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington's disease (HD). However, the crucial factors and the molecular mechanisms remain elusive. Here, we found that heat shock transcription factor 1 (HSF1) accumulates in the mitochondria of HD cell models, a YAC128 mouse model, and human striatal organoids derived from HD induced...

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PMID: 35670111
DOI: 10.15252/emmm.202215851

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