Article
A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathways.
Cancer epidemiology - 1 Jun 2016
Azad Abul Kalam, Bairati Isabelle, Qiu Xin, Girgis Hala, Cheng Lu, Waggott Daryl, Cheng Dangxiao, Mirshams Maryam, Ho James, Fortin André, Vigneault Eric, Huang Shao-Hui, O'Sullivan Brian, Waldron John, Boutros Paul C, Goldstein David, Meyer Francois, Xu Wei, Liu Geoffrey
Abstract excerpt
BACKGROUND: Carcinomas of the oral cavity, pharynx and larynx are referred to as head and neck cancers (HNC); together they account for 2-3% of all newly diagnosed cancers in North America. Between 40-50% of HNC are early diagnosed at stages I-II. The 5-year and 10-year relative survival rates are 61% and 50%, respectively. Germline genetic sequence variants (GSV) have become increasingly found to have prognostic...
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