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Article

Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers.

Cancer - 15 Mar 2012

Azad Abul Kalam, Bairati Isabelle, Samson Elodie, Cheng Dangxiao, Cheng Lu, Mirshams Maryam, Savas Sevtap, Waldron John, Wang Changshu, Goldstein David, Xu Wei, Meyer Francois, Liu Geoffrey

Abstract excerpt

BACKGROUND: Secondary primary cancers (SPCs), a major cause of morbidity and mortality in head and neck cancers (HNCs), are commonly associated with field cancerization. We comprehensively evaluated 23 germline sequence variants (from published literature) in 17 genes from 7 biological pathways associated with the HNC survival. Because cancer prognosis correlates with disease aggressiveness, the factors that...

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PMID: 22009713
DOI: 10.1002/cncr.26446

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