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Gene Polymorphisms of Epithelial Cell-Derived Alarmins and Their Effects on Protein Levels and Disease Severity in Patients with COVID-19.

Genes - 29 Aug 2023

Ranjbar Maral, Cusack Ruth P, Whetstone Christiane E, Nawaz Shiraz, Khoury Christopher, Wattie Jennifer, Wiltshire Lesley, Le Roux Jennifer, Cheng Eric, Srinathan Thivya, Ho Terence, Sehmi Roma, Duong MyLinh, Gauvreau Gail M

Abstract excerpt

BACKGROUND: The immune response in COVID-19 is characterized by the release of alarmin cytokines, which play crucial roles in immune activation and inflammation. The interplay between these cytokines and genetic variations may influence disease severity and outcomes, while sex differences might further contribute to variations in the immune response. METHODS: We measured the levels of alarmin cytokines in a...

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Identifiers

PMID: 37761861
DOI: 10.3390/genes14091721
PMCID: PMC10530834

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