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Article

(WNK)ing at death: With-no-lysine (Wnk) kinases in neuropathies and neuronal survival.

Brain research bulletin - 1 Jul 2016

Tang Bor Luen

Abstract excerpt

Members of With-no-lysine (WNK) family of serine-threonine kinase are key regulators of chloride ion transport in diverse cell types, controlling the activity and the surface expression of cation-chloride (Na(+)/K(+)-Cl(-)) co-transporters. Mutations in WNK1 and WNK4 are linked to a hereditary form of hypertension, and WNKs have been extensively investigated pertaining to their roles in renal epithelial ion...

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Source

Identifiers

PMID: 27131446
DOI: 10.1016/j.brainresbull.2016.04.017

Genes

WNK3
WNK1
WNK2
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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(WNK)ing at death: With-no-lysine (Wnk) kinases in neuropathies and neuronal survival.PMID 27131446Read ↗

WNKs: protein kinases with a unique kinase domain.Semantic proximity Read ↗

WNK kinases and essential hypertension.Semantic proximity Read ↗

WNK kinases and the kidney.Semantic proximity Read ↗

Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.Semantic proximity Read ↗

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.Semantic proximity Read ↗

Life and death of the distal nephron: WNK4 and NCC as major players.Semantic proximity Read ↗

Human hypertension caused by mutations in WNK kinases.Semantic proximity Read ↗

Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression.Semantic proximity Read ↗

Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.Semantic proximity Read ↗

WNK Kinases, Renal Ion Transport and HypertensionSemantic proximity Read ↗

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.Semantic proximity Read ↗

Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Semantic proximity Read ↗

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