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Article

Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.

CNS neuroscience & therapeutics - 1 Jan 2022

Peng Guangnan, Gu Ao, Niu Hongyan, Chen Linlin, Chen Yan, Zhou Miaojin, Zhang Yiti, Liu Jie, Cai Licong, Liang Desheng, Liu Xionghao, Liu Mujun

Abstract excerpt

AIMS: The ubiquilin-like protein ubiquilin 2 (UBQLN2) is associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). The biological function of UBQLN2 has previously been shown to be related to stress granules (SGs). In this study, we aimed to clarify the regulatory relationship between UBQLN2 and SGs. METHODS: In this study, we transfected UBQLN2-WT or UBQLN2-P497H plasmids into cell...

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PMID: 34750982
DOI: 10.1111/cns.13757
PMCID: PMC8673703

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