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Article

C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes.

Scientific reports - 12 May 2016

Kriegbaum Mette Camilla, Jacobsen Benedikte, Füchtbauer Annette, Hansen Gert Helge, Christensen Ib Jarle, Rundsten Carsten Friis, Persson Morten, Engelholm Lars Henning, Madsen Andreas Nygaard, Di Meo Ivano, Lund Ida Katrine, Holst Birgitte, Kjaer Andreas, Lærum Ole Didrik, Füchtbauer Ernst-Martin, Ploug Michael

Abstract excerpt

C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial evidence suggests a role for C4.4A in cell adhesion, migration, and invasion, but a well-defined...

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Identifiers

PMID: 27169360
DOI: 10.1038/srep25833
PMCID: PMC4864438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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