Article
Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese.
Genes and immunity - 1 Jan 2006
Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K
Abstract excerpt
Microscopic polyangiitis (MPA) is a rare and severe form of systemic necrotizing vasculitis associated with myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA). We previously reported significant association of HLA-DRB1*0901 with MPA. To define the susceptibility loci within the HLA region, we determined the genotypes of HLA-DQB1, DPB1, B and C in 50 patients with MPA and 77 unrelated...
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