A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells

Abstract excerpt

HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but weak HNF4α agonists alverine and benfluorex. Here, we administered NCT to mice fed a high fat diet, with the goal of studying the role of HNF4α in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Cell Function and Interaction
• Share to Pancreatic function and diabetes
• Share to Receptor Mechanisms and Signaling