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Hepatocyte nuclear factor 1α and β control terminal differentiation and cell fate commitment in the gut epithelium

13 Apr 2010

Abstract excerpt

The intestinal epithelium is a complex system characterized by massive and continuous cell renewal and differentiation. In this context, cell-type-specific transcription factors are thought to play a crucial role by modulating specific transcription networks and signalling pathways. Hnf1alpha and beta are closely related atypical homeoprotein transcription factors expressed in several epithelia, including the...

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PMID: 20388655
DOI: 10.1242/dev.044420

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