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Article

Signal transduction in mammalian oocytes during fertilization

9 Oct 2015

Abstract excerpt

Mammalian embryo development begins when the fertilizing sperm triggers a series of elevations in the oocyte's intracellular free Ca(2+) concentration. The elevations are the result of repeated release and re-uptake of Ca(2+) stored in the smooth endoplasmic reticulum. Ca(2+) release is primarily mediated by the phosphoinositide signaling system of the oocyte. The system is stimulated when the sperm causes the...

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PMID: 26453398
DOI: 10.1007/s00441-015-2291-8

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