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Article

Negative control of CSL gene transcription by stress/DNA damage response and p53

10 May 2016

Abstract excerpt

CSL is a key transcriptional repressor and mediator of Notch signaling. Despite wide interest in CSL, mechanisms responsible for its own regulation are little studied. CSL down-modulation in human dermal fibroblasts (HDFs) leads to conversion into cancer associated fibroblasts (CAF), promoting keratinocyte tumors. We show here that CSL transcript levels differ among HDF strains from different individuals, with...

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PMID: 27163456
DOI: 10.1080/15384101.2016.1186317

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