Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele.

Oncogene - 17 Feb 2005

da Costa Renata Maria Augusto, Riou Lydia, Paquola Apuã, Menck Carlos Frederico Martins, Sarasin Alain

Abstract excerpt

Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) syndromes are characterized by deficiency in nucleotide excision repair pathway, but with distinguished clinical manifestations. While XP patients exhibit a high frequency of skin cancer, TTD patients are not cancer prone. The relation between lack of DNA repair and their clinical manifestations was investigated through analysis of the transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cockayne Syndrome
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Hair Diseases

Share to Syndrome

Share to Ultraviolet Rays

Share to Up-Regulation

Share to Xeroderma Pigmentosum

Source

Identifiers

PMID: 15608684
DOI: 10.1038/sj.onc.1208288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiles of unirradiated or UV-irradiated human cells expressing either the cancer-prone XPB/CS allele or the noncancer-prone XPB/TTD allele.PMID 15608684Read ↗

Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy.Semantic proximity Read ↗

Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.Semantic proximity Read ↗

Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responsesSemantic proximity Read ↗

The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.Semantic proximity Read ↗

Do we know the cause of xeroderma pigmentosum?Semantic proximity Read ↗

Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.Semantic proximity Read ↗

The relative expression of mutated XPB genes results in xeroderma pigmentosum/Cockayne's syndrome or trichothiodystrophy cellular phenotypes.Semantic proximity Read ↗

Transcriptional consequences of XPA disruption in human cell lines.Semantic proximity Read ↗

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian CellsSemantic proximity Read ↗

Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.Semantic proximity Read ↗

Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells.Semantic proximity Read ↗

Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.