Article
Energy decomposition and waterswapping analysis to investigate the SNP associated DPD mediated 5-FU resistance.
SAR and QSAR in environmental research - 1 Jan 2023
Verma H, Doshi J, Narendra G, Raju B, Singh P K, Silakari O
Abstract excerpt
5-fluorouracil is an essential component of systemic chemotherapy for colon, breast, head, and neck cancer patients. However, tumoral overexpression of the dihydropyrimidine dehydrogenase has rendered 5-FU clinically ineffective by inactivating it to 5'-6'-dihydro fluorouracil. The responses to 5-FU in terms of efficacy and toxicity greatly differ depending upon the population group, because of variability in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.