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Article

A computational study on structural and functional consequences of nsSNPs in human dopa decarboxylase.

Journal of biomolecular structure & dynamics - 1 Mar 2025

Kumar S Birendra, Girish Aishwarya, Sutar Samruddhi, Premanand Suheeth Amberi, Garg Vrinda, Yadav Arvind Kumar, Shukla Rohit, Murthy T P Krishna, Singh Tiratha Raj

Abstract excerpt

The Dopa Decarboxylase (DDC) gene plays an important role in the synthesis of biogenic amines such as dopamine, serotonin, and histamine. Non-synonymous single nucleotide polymorphisms (nsSNPs) in the DDC gene have been linked with various neurodegenerative disorders. In this study, a comprehensive in silico analysis of nsSNPs in the DDC gene was conducted to assess their potential functional consequences and...

Read the complete abstract on PubMed

Topics

Humans
Dopa Decarboxylase
Molecular Dynamics Simulation
Polymorphism, Single Nucleotide
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Computational Biology

Parkinson Disease

Protein Conformation

Source

Identifiers

PMID: 38193892
DOI: 10.1080/07391102.2023.2301517

Genes

DDC

Provenance

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