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Skp2: A critical molecule for ubiquitination and its role in cancer

4 Jan 2024

Abstract excerpt

The ubiquitin-proteasome system (UPS) is a multi-step process that serves as the primary pathway for protein degradation within cells. UPS activity also plays a crucial role in regulating various life processes, including the cell cycle, signal transduction, DNA repair, and others. The F-box protein Skp2, a crucial member of the UPS, plays a central role in the development of various diseases. Skp2 controls...

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PMID: 38184273
DOI: 10.1016/j.lfs.2023.122409

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