Article
Complete sequence of human mitochondrial DNA obtained by combining multiple displacement amplification and next-generation sequencing on a single oocyte.
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Mar 2017
Ancora Massimo, Orsini Massimiliano, Colosimo Alessia, Marcacci Maurilia, Russo Valentina, De Santo Maria, D'Aurora Marco, Stuppia Liborio, Barboni Barbara, Cammà Cesare, Gatta Valentina
Abstract excerpt
Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondrial mutations could provide a better understanding of the...
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