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Mitochondrial DNA rearrangements in human oocytes and embryos

1 Oct 1999

Abstract excerpt

Human mitochondrial DNA (mtDNA) rearrangements, including more than 150 deletions and insertions, accumulate with age and are responsible for certain neuromuscular diseases. Human oocytes, arrested for up to 50 years, may express certain mtDNA rearrangements possibly affecting function. Investigations have previously shown a single mtDNA rearrangement (dmtDNA(4977)) in human oocytes. Sequencing of other...

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PMID: 10508220
DOI: 10.1093/molehr/5.10.927

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