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Article

Mitochondrial DNA variations in ova and blastocyst: implications in assisted reproduction.

Mitochondrion - 1 Mar 2013

Shamsi Monis Bilal, Govindaraj Periyasamy, Chawla Latika, Malhotra Neena, Singh Neeta, Mittal Suneeta, Talwar Pankaj, Thangaraj Kumarasamy, Dada Rima

Abstract excerpt

Mitochondrial DNA (mtDNA) of oocyte is critical for its function, embryo quality and development. Analysis of complete mtDNA of 49 oocytes and 18 blastocysts from 67 females opting for IVF revealed 437 nucleotide variations. 40.29% samples had either disease associated or non-synonymous novel or pathogenic mutation in evolutionarily conserved regions. Samples with disease associated mtDNA mutations had low...

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PMID: 23333796
DOI: 10.1016/j.mito.2013.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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