Article

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases

2020-01-18

Abstract excerpt

Osteoarthritis and rheumatoid arthritis are common cartilage and joint diseases that globally affect more than 200 and 20 million people, respectively. Several transcription factors have been implicated in the onset and progression of osteoarthritis, including Runx2, C/EBPβ, HIF2α, Sox4, and Sox11. IL-1β also leads to osteoarthritis through NF-ĸB, IκBζ, and Zn2+-ZIP8-MTF1 axis. IL-1, IL-...

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Literature Corpus work: 557b8e33-6eac-5df0-aa2b-2533c2cbe1bc
DOI: 10.20944/preprints202001.0199.v1

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