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Article

Activating transcription factor 4 regulates osteoclast differentiation in mice

13 Jul 2010

Abstract excerpt

Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Here, we targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice. OCL differentiation was drastically decreased in Atf4-/- bone marrow monocyte (BMM) cultures and...

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PMID: 20628199
DOI: 10.1172/jci42106

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