Article
An ErbB2 splice variant lacking exon 16 drives lung carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2020
Smith Harvey W, Yang Lei, Ling Chen, Walsh Arlan, Martinez Victor D, Boucher Jonathan, Zuo Dongmei, Sokol Ethan S, Pavlick Dean C, Frampton Garrett M, Chmielecki Juliann, Jones Laura M, Roux Philippe P, Lockwood William W, Muller William J
Abstract excerpt
Lung cancer causes more deaths annually than any other malignancy. A subset of non-small cell lung cancer (NSCLC) is driven by amplification and overexpression or activating mutation of the receptor tyrosine kinase (RTK) ERBB2 In some contexts, notably breast cancer, alternative splicing of ERBB2 causes skipping of exon 16, leading to the expression of an oncogenic ERBB2 isoform (ERBB2ΔEx16) that forms...
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