Article
Oncogenic variant RON160 expression in breast cancer and its potential as a therapeutic target by small molecule tyrosine kinase inhibitor.
Current cancer drug targets - 1 Jul 2013
Yao Hang-Ping, Zhuang Chun-Mei, Zhou Yong-Qing, Zeng Jun-Ying, Zhang Rui-Wen, Wang Ming-Hai
Abstract excerpt
Aberrant expression of the RON receptor tyrosine kinase contributes to breast cancer malignancy. Although clinical trials of RON targeting are underway, the intriguing issue is the diversity of RON expression as evident by cancer cells expressing different variants including oncogenic RON160. The current study determines aberrant RON160 expression in breast cancer and its potential as a target for breast cancer...
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