Article

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

2026-07-23

Abstract excerpt

Naturally occurring isoforms of the proto-oncogene Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2, HER2) incite unique pathways of tumor progression in mouse models of breast cancer. Although each isoform has been shown to progress to metastasis, the N-terminally truncated isoform (p95) was previously shown to be biased toward early distant dissemination prior to detection. Here we show how HER2 isoforms differentially...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b4c1c16-16f8-5362-8d50-457f45279499
DOI: 10.64898/2026.07.22.739975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signalingDOI 10.64898/2026.07.22.739975Read

Multiplex Imaging Reveals Novel Subcellular, Microenvironmental, and Racial Patterns of MRTFA/B Activation in Invasive Breast Cancers and MetastasesSemantic proximity Read

Pathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer.Semantic proximity Read

The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasionSemantic proximity Read

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migrationSemantic proximity Read

Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasisSemantic proximity Read

A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.Semantic proximity Read

Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potentialSemantic proximity Read

Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal TransitionSemantic proximity Read

Raman spectroscopy reveals phenotype switches in breast cancer metastasis.Semantic proximity Read

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer.Semantic proximity Read

A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and MetastasisSemantic proximity Read

The E2F Transcription Factors Regulate Tumor Development and Metastasis in a Mouse Model of Metastatic Breast CancerSemantic proximity Read