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Mechanism and role of H. pylori CagA-induced NLRP3 inflammasome in gastric cancer immune cell infiltration

24 Apr 2025

Abstract excerpt

The high incidence of gastric cancer in China is strongly associated with widespread Helicobacter pylori infection. While the bacterium's role in gastric cancer initiation and progression is well-established, the precise molecular mechanisms remain incompletely characterized. Current clinical challenges include limited early detection methods and poor therapeutic efficacy in advanced stages. Immune checkpoint...

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PMID: 40274924
DOI: 10.1038/s41598-025-98301-8

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