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Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori

1 Sept 2020

Abstract excerpt

Helicobacter pylori (Hp) is an important human pathogen associated with gastric inflammation and neoplasia. It is commonly believed that this bacterium avoids major immune recognition by Toll-like receptors (TLRs) because of low intrinsic activity of its flagellin and lipopolysaccharides (LPS). In particular, TLR5 specifically detects flagellins in various bacterial pathogens, while Hp evolved mutations in...

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PMID: 32937132
DOI: 10.1016/j.celrep.2020.108159

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