Article
Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing.
The Journal of molecular diagnostics : JMD - 1 Jul 2016
Armengol Gemma, Sarhadi Virinder K, Ghanbari Reza, Doghaei-Moghaddam Masoud, Ansari Reza, Sotoudeh Masoud, Puolakkainen Pauli, Kokkola Arto, Malekzadeh Reza, Knuutila Sakari
Abstract excerpt
Detection of driver gene mutations in stool DNA represents a promising noninvasive approach for screening colorectal cancer (CRC). Amplicon-based next-generation sequencing (NGS) is a good option to study mutations in many cancer genes simultaneously and from a low amount of DNA. Our aim was to assess the feasibility of identifying mutations in 22 cancer driver genes with Ion Torrent technology in stool DNA from...
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