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Article

Genetic mutations in human rectal cancers detected by targeted sequencing.

Journal of human genetics - 1 Oct 2015

Bai Jun, Gao Jinglong, Mao Zhijun, Wang Jianhua, Li Jianhui, Li Wensheng, Lei Yu, Li Shuaishuai, Wu Zhuo, Tang Chuanning, Jones Lindsey, Ye Hua, Lou Feng, Liu Zhiyuan, Dong Zhishou, Guo Baishuai, Huang Xue F, Chen Si-Yi, Zhang Enke

Abstract excerpt

Colorectal cancer (CRC) is widespread with significant mortality. Both inherited and sporadic mutations in various signaling pathways influence the development and progression of the cancer. Identifying genetic mutations in CRC is important for optimal patient treatment and many approaches currently exist to uncover these mutations, including next-generation sequencing (NGS) and commercially available kits. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26134512
DOI: 10.1038/jhg.2015.71
PMCID: PMC7514872

Genes

KRAS
APC
BRAF
CTNNB1
ERBB2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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