Article
Molecular status of PI3KCA, KRAS and BRAF in ovarian clear cell carcinoma: an analysis of 63 patients.
Journal of clinical pathology - 1 Dec 2016
Zannoni Gian Franco, Improta Giuseppina, Pettinato Angela, Brunelli Chiara, Troncone Giancarlo, Scambia Giovanni, Fraggetta Filippo
Abstract excerpt
AIMS: To evaluate the incidence of PI3KCA, KRAS and BRAF mutations in primary ovarian clear cell carcinoma (OCCC). METHODS: 63 consecutive patients, with a proven diagnosis of OCCC, according to WHO criteria, were included into the study. Pyrosequencing analysis of all three genes hotspot regions were performed on 2.5 µm sections of formalin-fixed paraffin-embedded tissue from primary OCCC. RESULTS: PI3KCA...
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