PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.

doi:10.3390/cells9020442

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.

Cells - 14 Feb 2020

D'Ambrosio Concetta, Erriquez Jessica, Arigoni Maddalena, Capellero Sonia, Mittica Gloria, Ghisoni Eleonora, Borella Fulvio, Katsaros Dionyssios, Privitera Silvana, Ribotta Marisa, Maldi Elena, Di Nardo Giovanna, Berrino Enrico, Venesio Tiziana, Ponzone Riccardo, Vaira Marco, Hall Douglas, Jimenez-Linan Mercedes, Paterson Anna L, Calogero Raffaele A, Brenton James D, Valabrega Giorgio, Di Renzo Maria Flavia, Olivero Martina

Abstract excerpt

Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of Patient-Derived Xenografts (PDXs) and performed copy number analysis and whole exome sequencing of 12 lines derived from naïve, high grade EOCs. Pyrosequencing allowed quantifying mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class Ia Phosphatidylinositol 3-Kinase

Share to Cystadenocarcinoma, Serous

Share to Heterografts

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplasm Grading

Share to Random Allocation

Source

Open in PubMed Open full text

Identifiers

PMID: 32075097
DOI: 10.3390/cells9020442
PMCID: PMC7072782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.PMID 32075097Read ↗

Identification of potentially actionable genetic variants in epithelial ovarian cancer: A retrospective cohort studySemantic proximity Read ↗

Epithelial ovarian cancer: rationale for changing the one-fits-all standard treatment regimen to subtype-specific treatment.Semantic proximity Read ↗

Exploring the somatic mutational landscape of ovarian cancer in Estonia.Semantic proximity Read ↗

Prevalence of pathogenic variants in actionable genes in advanced ovarian cancer: a next-generation sequencing analysis of a nationwide registry study.Semantic proximity Read ↗

Mutational heterogeneity in non-serous ovarian cancers.Semantic proximity Read ↗

Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach.Semantic proximity Read ↗

High throughput interrogation of somatic mutations in high grade serous cancer of the ovary.Semantic proximity Read ↗

Molecular diagnosis in type I epithelial ovarian cancer.Semantic proximity Read ↗

Somatic chromosomal number alterations affecting driver genes inform <i>in-vitro</i> and clinical drug response in high-grade serous ovarian cancerSemantic proximity Read ↗

Predictive modeling using a somatic mutational profile in ovarian high grade serous carcinoma.Semantic proximity Read ↗

Detection of somatic BRCA1/2 mutations in ovarian cancer - next-generation sequencing analysis of 100 cases.Semantic proximity Read ↗

Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.